What Are Your Bones Doing Right Now?

Good Morning.

Your bones may feel permanent, but they're changing all the time.

Bone is living tissue. Throughout your life, old bone is being removed while new bone is built in its place.

Most of the time, we never notice.

The body is remarkably good at keeping the two processes in balance. With age, however, rebuilding can have a harder time keeping pace with bone loss. Over time, bones can become weaker and more vulnerable to fractures.

Researchers in Germany have been investigating whether that balance can be changed.

Their attention is focused on a receptor called GPR133, which helps regulate cells involved in building bone. When researchers interfered with the receptor, bone became weaker.

Then they went in the other direction.

Using an experimental compound, researchers activated the receptor in mice. Bone formation increased while bone loss decreased. Even animals that already had osteoporosis-like bone loss developed stronger bones.

There's another reason the finding caught researchers' attention.

Earlier work from the same team suggests that activating GPR133 may also strengthen muscle.

That combination could be important. Stronger muscles help us stay stable and reduce the likelihood of falls. Stronger bones are better able to withstand a fall when one happens. Finding a way to support both could eventually offer a different approach to maintaining physical strength as we age.

Whether the same approach will work safely in people remains unknown.

But the research also tells us something interesting about the skeleton itself.

Our bones aren't structures we finish building when we're young and then spend the rest of our lives trying to preserve.

They're continually being renewed.

Now researchers are exploring whether that rebuilding process might someday be given a boost when it can no longer keep pace on its own.

Source: ScienceDaily, research published in Signal Transduction and Targeted Therapy

Longevity

The Long Game
One small thing for a longer life

Did You Know

The “5 a day” target may have an ideal mix.

Pooling data from studies involving about two million people, researchers found that eating five servings of fruits and vegetables a day was associated with the lowest risk of death, about 13% lower than eating two servings a day.

The combination linked to the greatest benefit? Two servings of fruit and three of vegetables. Eating more than five wasn't associated with additional longevity benefits, and fruit juice and starchy vegetables such as potatoes didn't show the same association.

Nutrition is one of the six factors that shape how well we age. The Worthyest Longevity Index measures all six in 4 minutes. Yours, personalized. Get my score →

Source: Wang et al., Circulation, 2021. Analysis of nearly 2 million adults.

The Curiosity Edit

Today’s Insight: Cancer Treatment

FDA Immediately Approves Drug That’s Doubling Lifespan for Late Pancreatic Cancer Patients

A new targeted drug is offering an important option for some people with advanced pancreatic cancer after chemotherapy stops working, with a late-stage trial showing a substantial improvement in survival. Read the full story here.

Modern Living:

Workplace Psychology

7 Signs You’ve Got a Toxic Boss

A difficult boss and a toxic one aren't necessarily the same thing. The difference often becomes clearer when certain behaviors start forming a pattern. Read the full story here.

Health & Wellness

When Everyday Changes Deserve Attention

Some changes are easy to dismiss as ordinary parts of life, but understanding what may be behind them can help us know when to pay closer attention. This collection looks at erectile dysfunction, memory lapses that may warrant a conversation with a doctor, and an intriguing connection between nap timing and body composition.

Forgetting These 4 Things Could Be a Sign of Something More Serious, Says Cleveland Clinic Expert
Occasional forgetfulness is a normal part of life, especially as we get older. An Alzheimer's specialist explains which kinds of memory lapses deserve more attention and how they can differ from the things most of us occasionally forget.

Napping at This Time Was Linked to Lower Body Fat & More Muscle
Napping is usually discussed in terms of energy and sleep, but researchers have found an interesting association with body composition. The findings suggest that when a nap happens could be part of the picture.

What Is Erectile Dysfunction?
Erectile dysfunction is common, but it can sometimes provide information about health beyond sexual function. Here's what can cause it, how doctors evaluate it, and the treatment options available.

The Conscious Plate:

Food, Nutrition & Elevated Living

What Belongs on the Plate

Nutrition choices aren't always as clear-cut as they seem. This collection looks at the difference between egg whites and whole eggs, when a supplement can be useful instead of a meal, and what eating a ketogenic diet actually involves.

Supplements vs. Real Meals: When Grabbing a Powder Makes Sense
Whole foods generally provide things a powder can't completely reproduce, but convenience and nutritional needs don't always cooperate. Here's when supplements can fill a useful role and when an actual meal remains the better choice.

Are Egg Whites Healthier Than Whole Eggs? What Nutrition Experts Say
Egg whites have long carried a healthier reputation, while the yolk has often been treated with more caution. Nutrition experts explain what each part of the egg provides and whether choosing one over the other makes nutritional sense.

Keto Diet: A Complete List of What to Eat and Avoid, Plus a 7-Day Sample Menu
Following a ketogenic diet requires more than simply cutting back on bread and pasta. This guide breaks down which foods fit, which don't, and the potential benefits and drawbacks worth understanding before trying it.

Final Note

This is what we leave you with. A thought to end the day, carry in your pocket, or come back to later. Nothing big. Just something to reflect on.

What We Choose Without Choosing

The things we reach for without thinking often say the most about us.

There are things we choose deliberately, and then there are the things we reach for without thinking. The same mug in the morning. The same chair in a room. The same person we call when something happens.

Those small habits can tell us a surprising amount about what we like, what makes us comfortable, and who matters to us.

Pass It On

Sometimes a thought, an idea, or a perspective connects at just the right time. If something here feels like it might resonate with someone you know, share it with them.

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